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Learn

Supplement guides &
interaction research.

Does Caffeine Blunt the Benefits of Creatine? The Research Is Mixed

Some studies show high caffeine intake reduces creatine's ergogenic effects during high-intensity exercise. The evidence is inconsistent, but the mechanism is worth understanding.

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Magnesium and Iron Share an Absorption Pathway at High Doses

High-dose magnesium competes with iron at intestinal transport sites. The effect is smaller than calcium-iron competition but relevant when both supplements are taken in large amounts.

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Selenium Protects the Thyroid When You're Supplementing High-Dose Iodine

Iodine drives thyroid hormone production, but excess iodine generates reactive oxygen species. Selenium-dependent enzymes neutralise them. The research on why both matter together.

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High Calcium Intake Reduces Zinc Absorption When Taken at the Same Time

Studies show calcium competes with zinc at intestinal absorption sites. The effect is dose-dependent and avoidable by spacing supplements two hours apart.

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Magnesium and Calcium Compete for Absorption at High Doses

At typical supplemental levels, the competition is minor. At high doses, studies show each mineral reduces the other's uptake. Here's what the evidence says and when it applies.

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High-Dose Vitamin E Has Anticoagulant Properties. Warfarin Users Need to Monitor

Supplemental vitamin E above 400 IU per day can inhibit vitamin K-dependent clotting factors and potentiate warfarin. Here's what studies found about the mechanism and risk.

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Ashwagandha Appears to Raise Thyroid Hormone Levels. Medication Users Should Monitor

Clinical studies show ashwagandha increases T3 and T4 concentrations. For those on levothyroxine or other thyroid drugs, that amplification warrants monitoring.

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Berberine and Metformin Work the Same Way. Combined, Blood Sugar Can Drop Too Far

Both activate AMPK, the enzyme regulating glucose metabolism. Research shows their combined glucose-lowering effect increases hypoglycaemia risk in ways that deserve monitoring.

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Ginkgo Biloba and Aspirin Both Reduce Platelet Clumping. Together, the Effect Adds Up

Ginkgo has independent antiplatelet activity. Added to aspirin, the combined effect on bleeding time is greater than either alone. The case reports and mechanism explained.

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Melatonin Amplifies Sedative Medications. Researchers Quantify the Risk

Melatonin has been shown to potentiate benzodiazepines and other prescribed sedatives, increasing impairment beyond what either produces alone. Here's what the studies found.

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Too Much Vitamin A Can Work Against Your Vitamin D Supplementation

High retinol intake competes with vitamin D for shared nuclear receptors. Research suggests this may blunt vitamin D's biological effects, particularly above 5000 IU of retinol per day.

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High-Dose Vitamin C May Destroy Vitamin B12 in Your Stomach

A study found that 500mg or more of vitamin C chemically degrades B12 when both are present together. The fix is simple: separate them by at least two hours.

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Zinc and Iron Share an Absorption Pathway. High Doses Cause Real Competition

Both minerals use the same intestinal transporter, DMT1. At supplemental doses above 50mg, zinc significantly reduces iron absorption. Here's what the research found.

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Mixing Melatonin and Alcohol Backfires. Here's What the Research Shows

Both alcohol and melatonin depress the central nervous system. Research shows combining them causes excessive sedation and actually disrupts the sleep architecture you were trying to improve.

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High Folate Intake Can Hide a B12 Deficiency. The Neurological Damage Is Real

Folate corrects the anaemia of B12 deficiency without touching the underlying nerve damage. Left undetected, that damage progresses to permanent neurological harm.

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Ginkgo Biloba and Warfarin: A Bleeding Risk the Case Reports Confirm

Ginkgo inhibits platelet activating factor and may amplify warfarin's anticoagulant effect. Case reports of serious bleeding have prompted clinical warnings.

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Tyrosine Supplements and MAO Inhibitors Can Trigger a Hypertensive Crisis

Tyrosine is converted into adrenaline and dopamine. MAO inhibitors block their breakdown. The pressure surge that results can be dangerous and rapid.

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5-HTP and SSRIs: Why This Combination Raises Serotonin Syndrome Risk

5-HTP increases serotonin production. SSRIs prevent its reuptake. Together, serotonin accumulates beyond safe levels. Here's the pharmacology and the clinical picture.

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St John's Wort Has Been Linked to Contraceptive Failure

By inducing the liver enzyme that metabolises oral contraceptives, St John's Wort can reduce hormone levels below the threshold needed for reliable contraception.

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Magnesium Forms Explained: Glycinate vs Malate vs Oxide

Magnesium comes in many forms, and the differences matter. Here's which form to choose based on your goal, and why the cheapest option is often the worst.

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High-Dose Fish Oil Can Thin Your Blood Further. Warfarin Users Need to Know

Omega-3 fatty acids at doses above 3g/day have documented antiplatelet effects. Researchers have flagged the interaction with warfarin and other blood-thinning medications.

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St John's Wort and Antidepressants: A Combination Clinicians Warn Against

St John's Wort raises serotonin activity and alters how the body processes drugs. Combined with SSRIs or SNRIs, the risk of serotonin syndrome is well-documented.

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High-Dose Zinc Depletes Copper Over Time. The Evidence Is Solid

Zinc supplementation above 40mg per day induces a protein that traps copper in gut cells before it can be absorbed. Here's what the research measured and when to worry.

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Vitamin D and K2: Why This Pairing Is About Calcium, Not Just Bone Density

Vitamin D drives calcium absorption. K2 directs where it goes. Research suggests that taking high-dose D without K2 may increase calcium deposition in arteries.

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The No-Nonsense Guide to Creatine

Creatine is one of the most researched supplements in existence. Here's what forms to buy, how to dose it, when to take it, and what to look for in a brand.

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Without Enough Magnesium, Your Vitamin D Supplement May Not Work

A 2018 paper found that magnesium is a required cofactor at every enzymatic step of vitamin D metabolism. Low magnesium can render vitamin D supplementation ineffective.

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Vitamin C Dramatically Boosts the Iron You Absorb. Here's the Research

Combining vitamin C with non-heme iron at the same meal can double or triple absorption. A classic study explains the chemistry and how large the effect really is.

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Why Calcium and Iron Supplements Don't Belong in the Same Glass

A landmark study showed that 600mg of calcium can cut iron absorption by up to 60%. Here's what the research found and what it means for your daily stack.

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What Is a Supplement Stack, and Why Should You Track One?

A supplement stack is a combination of supplements taken together to achieve a specific health goal. Here's what that means, why people build them, and how Biostacks helps you manage yours.

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